Antibacterial activities of Cameroonian spices & their synergistic effects w antibiotics against multidrug-resistant phenotypes

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Antibacterial activities of Cameroonian spices & their synergistic effects w antibiotics against multidrug-resistant phenotypes

 

Fankam AG, Kuete V, Voukeng IK, et al. Antibacterial activities of selected Cameroonian spices and their synergistic effects with antibiotics against multidrug-resistant phenotypes. BMC Complement Altern Med 2011 Nov 1;11:104.

 

doi:10.1186/1472-6882-11-104

 

http://www.biomedcentral.com/1472-6882/11/104/abstract

http://www.biomedcentral.com/content/pdf/1472-6882-11-104.pdf

 

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Background

The emergence of multi-drug resistant (MDR) phenotypes is a major public health problem today in the treatment of bacterial infections. The present study was designed to evaluate the antibacterial activities of the methanol extracts of eleven Cameroonian spices on a panel of twenty nine Gram negative bacteria including MDR strains.

Methods

The phytochemical analysis of the extracts was carried out by standard tests meanwhile the liquid micro-broth dilution was used for all antimicrobial assays.

Results

Phytochemical analysis showed the presence of alkaloids, phenols and tannins in all plants extracts. The results of the antibacterial assays indicated that all tested extracts exert antibacterial activities, with the minimum inhibitory concentration (MIC) values varying from 32 to 1024 ug/ml. The extracts from Dichrostachys glomerata, Beilschmiedia cinnamomea, Aframomum citratum, Piper capense, Echinops giganteus, Fagara xanthoxyloides and Olax subscorpioidea were the most active. In the presence of efux pump inhibitor, PASZN, the activity of the extract from D. glomerata significantly increased on 69.2 % of the tested MDR bacteria. At MIC/5, synergistic effects were noted with the extract of D. glomerata on 75% of the tested bacteria for chloramphenicol (CHL), tetracycline (TET) and norfloxacin (NOR). With B. cinnamomea synergy were observed on 62.5 % of the studied MDR bacteria with CHL, cefepime (FEP), NOR and ciprofloxacin (CIP) and 75% with erythromycin (ERY).

Conclusion

The overall results provide information for the possible use of the studied extracts of the spices in the control of bacterial infections involving MDR phenotypes.