Tretli S, Hernes E, Berg JP, et al. Association between serum 25(OH)D and death from prostate cancer. Br J Cancer 2009 Feb 3;100(3):450-454.
doi:10.1038/sj.bjc.6604865
http://www.nature.com/bjc/journal/v100/n3/abs/6604865a.html
http://www.nature.com/bjc/journal/v100/n3/full/6604865a.html
http://www.nature.com/bjc/journal/v100/n3/pdf/6604865a.pdf
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Clinical Study
British Journal of Cancer (2009) 100, 450–454. doi:10.1038/sj.bjc.6604865 www.bjcancer.com
Published online 20 January 2009
Association between serum 25(OH)D and death from prostate cancer
S Tretli1,2, E Hernes1,3, J P Berg4,5, U E Hestvik1 and T E Robsahm1
. 1The Cancer Registry of Norway, Institute of Population-based Cancer Research, Oslo, Norway
. 2Department of Community Medicine and General Practice, NTNU, Trondheim, Norway
. 3The Norwegian Radium Hospital, Montebello, Norway
. 4Hormone Laboratory, Aker University Hospital, Oslo, Norway
. 5Faculty Division Ullevål University Hospital, University of Oslo, Oslo, Norway
Correspondence: Dr TE Robsahm, The Cancer Registry of Norway, Institute of Population-based Cancer Research, PB 5313, Majorstua, Oslo 0304, Norway; E-mail:
Received 23 September 2008; Revised 2 December 2008; Accepted 5 December 2008; Published online 20 January 2009.
Abstract
Based on observations that for certain cancers, mortality varies according to sun exposure, vitamin D has been proposed to influence on disease progression. This study aims to investigate whether serum levels of 25(OH)D are associated with prognosis in patients with prostate cancer. In total, 160 patients with a serum sample in the JANUS serum bank were included. For 123 patients a pre-treatment serum sample was taken, whereas 37 of the patients had received hormone therapy prior to the blood collection. The serum level of 25(OH)D was classified as low (80 nmol l-1). A Cox proportional hazard regression model was used to assess the association between serum 25(OH)D and cancer mortality. During follow-up, 61 deaths occurred, of whom 52 died of prostate cancer. The median time of follow-up was 44.0 months (range, 1.2–154.6). Serum 25(OH)D at medium or high levels were significantly related to better prognosis (RR 0.33; 95% CI 0.14–0.77, RR 0.16; 95% CI 0.05–0.43) compared with the low level. Analysis restricted to patients receiving hormone therapy gave a stronger association. The serum level of 25(OH)D may be involved in disease progression and is a potential marker of prognosis in patients with prostate cancer.
Keywords: 25(OH)D, serum, prostate cancer, prognosis, mortality
© 2009 Cancer Research UK