Bicarbonate Slows Chronic Kidney Disease

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Bicarbonate Slows Chronic Kidney Disease

de Brito-Ashurst I, Varagunam M, Raftery MJ, Yaqoob MM. Bicarbonate supplementation slows progression of CKD and improves nutritional status. J Am Soc Nephrol 2009;DOI: 10.1681/ASN.2008111205.


Published ahead of print on July 16, 2009
Journal of the American Society of Nephrology
© 2009 American Society of Nephrology
doi: 10.1681/ASN.2008111205

Received November 24, 2008
Accepted on May 18, 2009

Bicarbonate Supplementation Slows Progression of CKD and Improves Nutritional Status
Ione de Brito-Ashurst , Mira Varagunam , Martin J. Raftery , and Muhammad M. Yaqoob 1

Department of Renal Medicine and Transplantation, William Harvey Research Institute and Barts and the London NHS Trust, London, United Kingdom

1 To whom correspondence should be addressed. E-mail:



Bicarbonate supplementation preserves renal function in experimental chronic kidney disease (CKD), but whether the same benefit occurs in humans is unknown. Here, we randomly assigned 134 adult patients with CKD (creatinine clearance [CrCl] 15 to 30 ml/min per 1.73 m2) and serum bicarbonate 16 to 20 mmol/L to either supplementation with oral sodium bicarbonate or standard care for 2 yr. The primary end points were rate of CrCl decline, the proportion of patients with rapid decline of CrCl (>3 ml/min per 1.73 m2/yr), and ESRD (CrCl

Copyright © 2009 by the American Society of Nephrology.