Hazra A, Kraft P, Selhub J, et al. Common variants of FUT2 are associated with plasma vitamin B(12) levels. Nat Genet 2008 Sep 7. [Epub ahead of print]
PMID: 18776911
http://www.nature.com/ng/journal/vaop/ncurrent/abs/ng.210.html
http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.210.html
http://www.nature.com/ng/journal/vaop/ncurrent/pdf/ng.210.pdf
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Nat Genet. 2008 Sep 7. [Epub ahead of print]
Common variants of FUT2 are associated with plasma vitamin B(12) levels.
Hazra A, Kraft P, Selhub J, Giovannucci EL, Thomas G, Hoover RN, Chanock SJ, Hunter DJ.
[1] Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, Massachusetts 02115, USA. [2] Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, Massachusetts 02115, USA.
We identified a strong association (P = 5.36 x 10(-17)) between rs492602 in FUT2 and plasma vitamin B(12) levels in a genome-wide scan (n = 1,658) and an independent replication sample (n = 1,059) from the Nurses' Health Study. Women homozygous for the rs492602[G] allele had higher B(12) levels. This allele is in strong linkage disequilibrium with the FUT2 nonsecretor variant encoding W143X, suggesting a plausible mechanism for altered B(12) absorption and plasma levels.
PMID: 18776911