Srinivasan M, Irving BA, Dhatariya K, et al. Effect of dehydroepiandrosterone replacement on lipoprotein profile in hypoadrenal women. J Clin Endocrinol Metab 2009 Mar;94(3):761-764.
http://jcem.endojournals.org/cgi/content/abstract/94/3/761
http://jcem.endojournals.org/cgi/content/full/94/3/761
http://jcem.endojournals.org/cgi/reprint/94/3/761
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J Clin Endocrinol Metab. 2009 Mar;94(3):761-4. Epub 2008 Dec 9.
Effect of dehydroepiandrosterone replacement on lipoprotein profile in hypoadrenal women.
Srinivasan M, Irving BA, Dhatariya K, Klaus KA, Hartman SJ, McConnell JP, Nair KS.
Division of Endocrinology, Endocrine Research Unit, Mayo Clinic and Mayo Foundation,, Rochester, Minnesota 55905, USA.
CONTEXT: Levels of dehydroepiandrosterone (DHEA) and its sulfate form (DHEAS) are inversely associated with cardiovascular mortality in men but not women. Very little evidence is available on the impact of DHEA administration on lipoprotein profile in women. DHEAS levels are very low/undetectable in hypoadrenal women. OBJECTIVE: The objective of the study was to determine the impact of DHEA replacement on lipoprotein profile in hypoadrenal women. DESIGN AND SETTING: A double-blind, randomized, placebo-controlled, cross-over design study was conducted at the Mayo Clinic. PARTICIPANTS: Thirty-three hypoadrenal Caucasian women (mean +/- sd; age 50.3 +/- 15.2 yr, body mass index 26.6 +/- 4.4 kg/m(2)) took part in the study. INTERVENTION: Study participants were assigned to receive either a placebo or 50 mg/d of DHEA for 3 months each. Lipid levels and lipoprotein profile were analyzed using the Lipo Science Lipoprotein nuclear magnetic resonance system. MAIN OUTCOME MEASURES: Changes in various lipoprotein sizes and levels were measured. RESULTS: The DHEA period had higher plasma DHEAS levels than during placebo (
PMID: 19066301