Ivermectin primarily targets and affects the nervous system of parasites, including various types of worms and certain ectoparasites (parasites that live on the outside of the body). It works by binding to specific receptors known as glutamate-gated chloride channels (GluCls) present in nerve and muscle cells of parasites.
By interacting with these receptors, ivermectin interferes with the normal functioning of neurotransmitters like gamma-aminobutyric acid (GABA) in the parasite's nervous system. This disruption leads to an increase in chloride ion influx into the nerve and muscle cells, causing hyperpolarization and paralysis of the parasites.
The specific targets of ivermectin can vary depending on the type of parasite. It is effective against various nematodes (roundworms) and arthropods such as lice and mites. For example, in the case of parasitic worms, ivermectin targets their nervous system and musculature, leading to paralysis and ultimately their elimination from the body.
It is important to note that while ivermectin is highly effective against parasites, it does not target or affect human or mammalian cells in the same way. This is due to the differences in the receptor structures between parasites and humans, which minimizes the impact of ivermectin on human health when used appropriately.
The specific target and mode of action of ivermectin may vary depending on the type of parasite being treated. It is always essential to use ivermectin under the guidance of a healthcare professional who can accurately diagnose the condition, prescribe the appropriate dosage, and provide necessary precautions or potential side effects to watch out for.Buy Ivermectin Cream UK is used in the treatment of Rosacea, and Parasitic Skin infections.