Zhewitra 60 mg contains Vardenafil as its active ingredient, and it is primarily used to treat erectile dysfunction (ED) in men. Vardenafil belongs to a class of medications known as phosphodiesterase type 5 (PDE5) inhibitors. Let's explore how Zhewitra 60 mg works on a physiological level to improve erectile function:
Inhibition of PDE5: When a man is sexually aroused, nitric oxide is released in the erectile tissue of the penis. Nitric oxide stimulates an enzyme called guanylate cyclase, which leads to an increase in the levels of cyclic guanosine monophosphate (cGMP). This cGMP is crucial for relaxing the smooth muscles in the penile blood vessels, allowing them to dilate and increase blood flow to the penis. The increased blood flow is what causes an erection.
Sustaining Erection: To maintain an erection, cGMP needs to be present in sufficient quantities. However, an enzyme called PDE5 breaks down cGMP, leading to a reduction in its levels and loss of the erection. Zhewitra 60 mg inhibits the action of PDE5, preventing it from breaking down cGMP. This results in increased cGMP levels, prolonged relaxation of penile blood vessels, and better blood flow, leading to a sustained erection.
Sexual Stimulation: It's important to note that Zhewitra 60 mg works when there is sexual stimulation. It does not cause an erection on its own; sexual arousal is still required. When sexual activity is complete, the erection should naturally subside. If the erection persists for more than four hours (priapism), it is considered a medical emergency, and immediate medical attention should be sought to prevent potential complications.
Dosage Considerations: The dosage of Zhewitra or any other vardenafil-based medication should be determined by a healthcare professional based on individual health conditions, medical history, and other medications a person may be taking. Taking the correct dosage is essential for the safe and effective use of the medication.