Kamagra 50 mg contains sildenafil citrate, a phosphodiesterase type 5 (PDE5) inhibitor. The primary mechanism of action of sildenafil involves its effects on the enzyme PDE5, which is found in various tissues, including the smooth muscle of the corpus cavernosum in the penis.
Here's a simplified explanation of how Kamagra works:
Relaxation of Smooth Muscles: In the presence of sexual stimulation, nitric oxide is released in the erectile tissue of the penis. Nitric oxide activates an enzyme called guanylate cyclase, which increases levels of cyclic guanosine monophosphate (cGMP).
Increased cGMP Levels: cGMP is a signaling molecule that plays a crucial role in the relaxation of smooth muscle cells. Increased levels of cGMP cause the smooth muscles in the blood vessels of the penis to relax, allowing more blood to flow into the erectile tissues.
Enhanced Blood Flow: The relaxation of smooth muscles and the increased levels of cGMP result in improved blood flow to the penis. This increased blood flow is what helps men with erectile dysfunction achieve and maintain an erection.
PDE5 Inhibition: Normally, cGMP is broken down by the enzyme PDE5. Sildenafil in Kamagra inhibits PDE5, preventing the rapid breakdown of cGMP. This allows cGMP to accumulate, prolonging the vasodilatory effects and maintaining a sufficient blood flow for a longer duration.
It's important to note that the effects of Kamagra are localized to the genital area, primarily affecting the penis. While sildenafil can also have mild systemic effects on blood vessels in other parts of the body, its primary therapeutic action is directed towards the treatment of erectile dysfunction.